Effect of angiotensin II on total plasma protein and albumin content in dogs.

Intravenous administration of angiotensin II caused a significant decrease in total plasma protein and albumin level in dogs. The central nervous system, the spleen and adrenal glands do not play any significant role in decreased plasma protein and albumin level. It is suggested that might be due to increased secretion of prostaglandin-like substances from the dog kidney causing increased permeability of vascularendothelium.