Hypocholesterolemic response to angiotensin II in dogs.

Intravenous administration of angiotensin II caused a significant decrease in blood choelsterol level in dogs. This hypocholesterolaemic response, also obtained in spinal vagotomized and adrenalectomized dogs, indicates that central nervous system and adrenals have no role in angiotension II induced hypocholesterolemic effect. In hepatectomized dogs in which both vagi were intact intravenously administered angiotensin did not cause any significant decrease in blood choelsterol level, suggesting that angiotensin exerts its effect by inhibiting the synthesis or preventing the release of cholesterol from the liver.