Tomizawa S, Suzuki S, Kuroume T, Morikawa A, Matsui A, Fukasawa T, Matsumura T
Int Arch Allergy Appl Immunol. 1977;54(5):400-4. doi: 10.1159/000231854.
The immediate skin reaction (IR) with streptokinase-streptodornase (SK-SD) was found with a high incidence in children with renal disease and was confirmed to be mediated by a specific IgE antibody against SK-SD by means of the radioallergosorbent test (RAST). This test revealed high radiocounts in children with renal disease who showed the IR and there was a close correlation between the RAST counts and the intensity of the IR. Furthermore, the RAST counts in the severe nephrotic syndrome belonging to corticosteroid dependent and resistant group were far higher than those in the corticosteroid sensitive group. From these results, a determination of the RAST counts against SK-SD seemed to help evaluate the severity of some nephrotic syndromes and the specific IgE antibody may be involved in the pathogenesis of the disease.
在肾病患儿中发现链激酶-链道酶（SK-SD）引起的即刻皮肤反应（IR）发生率很高，并且通过放射变应原吸附试验（RAST）证实其由针对SK-SD的特异性IgE抗体介导。该试验显示，出现IR的肾病患儿放射性计数较高，且RAST计数与IR强度之间存在密切相关性。此外，属于皮质类固醇依赖和抵抗组的重度肾病综合征患儿的RAST计数远高于皮质类固醇敏感组。根据这些结果，测定针对SK-SD的RAST计数似乎有助于评估某些肾病综合征的严重程度，且特异性IgE抗体可能参与了该疾病的发病机制。
