Hassett D E, Whitton J L
Dept of Neuropharmacology, Scripps Research Insitute, La Jolla, CA 92037, USA.
Trends Microbiol. 1996 Aug;4(8):307-12. doi: 10.1016/0966-842x(96)10048-2.
Inoculation with plasmid DNA vectors encoding immunogenic proteins induces both humoral and cell-mediated immune responses, which often provide protective immunity. Although many questions regarding the mechanism, efficacy and safety of DNA immunization remain to be addressed, this approach may offer a safer and more cost-effective alternative to conventional vaccines.