芬苯达唑和甲苯达唑对猪肾虫齿冠尾线虫某些酶的影响的研究
Studies on the effect of fenbendazole and mebendazole on some enzymes of swine kidney worm Stephanurus dentatus.
作者信息
Singh K, Kaushal P
机构信息
Pest and Parasite Research Laboratory, Postgraduate Department of Zoology, Bareilly College, India.
出版信息
Appl Parasitol. 1996 Sep;37(3):217-23.
The effect of fenbendazole and mebendazole on the activity of some enzymes of the homogenates of swine kidney worm Stephanurus dentatus was investigated. Fenbendazole at 10(-5) M inhibited malate oxidation by 49% and 51% and oxaloacetate reduction by 33% and 40% whereas, mebendazole at 10(-5) M diminished malate oxidation by 25% and 35% and oxaloacetate reduction by 12% and 14% in male and female S. dentatus, respectively. Lactate dehydrogenase activity was inhibited by 45% and 50% in male and female worm respectively by 10(-5) M fenbendazole. Aldolase activity in both male and female S. dentatus was inhibited by 10(-5) M fenbendazole and mebendazole. Fenbendazole at 10(-5) M caused moderate inhibition of acid and alkaline phosphomonoesterases but mebendazole did not show a significant effect on these enzymes. Cholinesterase activity was not affected significantly with either compound. The possible mode of action of the two compounds is compared.
研究了芬苯达唑和甲苯达唑对猪肾虫齿冠尾线虫匀浆中某些酶活性的影响。10⁻⁵M的芬苯达唑使雄性和雌性齿冠尾线虫中苹果酸氧化分别受到49%和51%的抑制，草酰乙酸还原分别受到33%和40%的抑制；而10⁻⁵M的甲苯达唑使雄性和雌性齿冠尾线虫中苹果酸氧化分别减少25%和35%，草酰乙酸还原分别减少12%和14%。10⁻⁵M的芬苯达唑使雄性和雌性虫体中的乳酸脱氢酶活性分别受到45%和50%的抑制。10⁻⁵M的芬苯达唑和甲苯达唑均抑制雄性和雌性齿冠尾线虫中的醛缩酶活性。10⁻⁵M的芬苯达唑对酸性和碱性磷酸单酯酶有中度抑制作用，但甲苯达唑对这些酶没有显著影响。两种化合物对胆碱酯酶活性均无显著影响。比较了这两种化合物可能的作用方式。
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