Morimoto R I, Kroeger P E, Cotto J J
Department of Biochemistry, Molecular Biology and Cell Biology Northwestern University, Evanston, IL 60208, USA.
EXS. 1996;77:139-63. doi: 10.1007/978-3-0348-9088-5_10.
The inducible regulation of heat shock gene transcription is mediated by a family of heat shock factors (HSF) that respond to diverse forms of physiological and environmental stress including elevated temperature, amino acid analogs, heavy metals, oxidative stress, anti-inflammatory drugs, arachidonic acid, and a number of pathophysiological disease states. The vertebrate genome encodes a family of HSFs which are expressed ubiquitously, yet the DNA binding properties of each factor are negatively regulated and activated in response to specific conditions. This chapter will discuss the regulation of the HSF multi-gene family and the role of these transcriptional activators in the inducible expression of genes encoding heat shock proteins and molecular chaperones.
热休克基因转录的诱导性调控是由热休克因子（HSF）家族介导的，这些因子可对多种形式的生理和环境应激作出反应，包括温度升高、氨基酸类似物、重金属、氧化应激、抗炎药物、花生四烯酸以及一些病理生理疾病状态。脊椎动物基因组编码一个普遍表达的HSF家族，然而每个因子的DNA结合特性在特定条件下受到负调控并被激活。本章将讨论HSF多基因家族的调控以及这些转录激活因子在编码热休克蛋白和分子伴侣的基因的诱导性表达中的作用。
