Heger G, Howorka K, Thoma H, Tribl G, Zeitlhofer J
Department of Biomedical Engineering and Physics, University of Vienna, Austria.
Med Biol Eng Comput. 1996 Jan;34(1):69-75. doi: 10.1007/BF02637024.
Recurrent severe hypoglycaemia is often an unsolved problem in diabetic patients under intensified insulin treatment. As no reliable long-term stable blood glucose sensor has yet been developed, registration of other body function changes could help to detect severe hypoglycaemia. A measuring system is described, capable on the one hand of recording EEG, heart rate, peripheral pulse, skin temperature, respiratory movements, skin impedance and arterial blood pressure, and capable of registering plasma glucose, counter-regulatory hormones, symptoms and cognitive performance under experimental conditions during hypoglycaemia, on the other. In a clinical study involving both insulin-induced hypoglycaemia in healthy subjects and insulin-dependent diabetic patients, the practical value and the character of changes of the recorded parameters are investigated. Currently insensitivity to hypoglycaemia, impracticability, complexity or susceptibility to artefacts make use of most parameters unsuitable for hypoglycaemia prevention. It is believed, however, that future efforts could result in indirect registration of hypoglycaemia, including a qualified combination of different parameters, individual adaptation in accordance with particular responses of individual patients, together with new measuring and sensor techniques.
在强化胰岛素治疗的糖尿病患者中,反复发生严重低血糖往往是一个尚未解决的问题。由于尚未开发出可靠的长期稳定血糖传感器,记录其他身体功能变化可能有助于检测严重低血糖。本文描述了一种测量系统,该系统一方面能够记录脑电图、心率、外周脉搏、皮肤温度、呼吸运动、皮肤阻抗和动脉血压,另一方面能够在低血糖实验条件下记录血浆葡萄糖、反调节激素、症状和认知表现。在一项涉及健康受试者和胰岛素依赖型糖尿病患者胰岛素诱导低血糖的临床研究中,对记录参数的实用价值和变化特征进行了研究。目前,对低血糖不敏感、不实用、复杂或易受伪影影响,使得大多数参数不适用于预防低血糖。然而,人们相信,未来的努力可能会实现低血糖的间接记录,包括不同参数的合理组合、根据个体患者的特定反应进行个体调整,以及新的测量和传感技术。