Wilson I D
Department of Safety of Medicines, Zeneca Pharmaceuticals, Cheshire, England.
Ther Drug Monit. 1996 Aug;18(4):484-92. doi: 10.1097/00007691-199608000-00030.
Thin-layer (or planar) chromatography (TLC) is critically reviewed from the point of view of drug analysis in biological fluids. The capabilities of the various techniques of TLC are described and their advantages and disadvantages are discussed. An example of the use of high-performance TLC with scanning densitometry for the quantitative determination of antipyrine in human plasma is provided. The use of TLC-mass spectrometry and TLC-tandem mass spectrometry, directly from the sorbent, in the identification of the compounds separated by TLC is discussed.
从生物流体中药物分析的角度对薄层（或平面）色谱法（TLC）进行了批判性综述。描述了TLC各种技术的能力，并讨论了它们的优缺点。提供了一个使用高效薄层色谱法和扫描密度计定量测定人血浆中安替比林的示例。讨论了直接从吸附剂上使用TLC-质谱联用和TLC-串联质谱联用技术鉴定TLC分离的化合物的方法。
