McLachlan R S, Levin S, Blume W T
Department of Clinical Neurological Sciences, University of Western Ontario, London, Canada.
Neurology. 1996 Oct;47(4):925-8. doi: 10.1212/wnl.47.4.925.
Since cytomegalovirus (CMV) has been implicated in the pathogenesis of Rasmussen's syndrome, we treated four patients with ganciclovir, a potent anti-CMV drug. A 7-year-old girl with seizures escalating to 60/day over 3 months despite triple antiepileptic drug therapy became seizure-free 5 days after initiation of treatment with no recurrence at 1.5 years follow-up. Focal neurologic signs, cognitive function, and the EEG returned to normal. Two patients treated 34 and 72 months after disease onset in association with epilepsy surgery had a reduction in seizures and one had no response. CMV genome was detected in the brains of two of the three patients in whom it was assessed. The response to antiviral therapy supports a viral etiology for chronic encephalitis of Rasmussen. If the disease is suspected, treatment with ganciclovir should be considered as early as possible.
由于巨细胞病毒（CMV）与拉斯穆森综合征的发病机制有关，我们用更昔洛韦（一种有效的抗CMV药物）治疗了4例患者。一名7岁女孩，尽管接受了三联抗癫痫药物治疗，但癫痫发作在3个月内增至每天60次，在开始治疗5天后癫痫发作停止，随访1.5年无复发。局灶性神经体征、认知功能和脑电图恢复正常。另外两名在疾病发作后34个月和72个月接受治疗并联合癫痫手术的患者癫痫发作减少，还有一名患者无反应。在接受评估的3例患者中，有2例在大脑中检测到CMV基因组。抗病毒治疗的反应支持拉斯穆森慢性脑炎的病毒病因。如果怀疑患有该病，应尽早考虑用更昔洛韦治疗。
