通过局部应用二甲亚砜预防伤口边缘坏死。
Prevention of wound edge necrosis by local application of dimethylsulfoxide.
作者信息
Celen O, Yildirim E, Berberoğlu U
机构信息
Department of Surgery, Ankara Oncology Teaching and Research Hospital, Ankara, Turkey.
出版信息
Acta Chir Belg. 2005 May-Jun;105(3):287-90. doi: 10.1080/00015458.2005.11679718.
BACKGROUND
Surgical flap necrosis is one of the most common problems after procedures such as mastectomies and regional lymph node dissections. In this prospective randomized study, the effect of topical dimethylsulfoxide (DMSO) on skin flap viability was analyzed.
MATERIAL AND METHODS
Sixty-six consecutive patients with breast cancer who had skin flaps created during mastectomy were randomized into two groups. Topical DMSO was applied on surgical flaps of the patients in Group-1, topical saline was applied for those in Group-2. Necrotic flap edges were recorded during the follow-up period for each patient, then excised and weighted in a blind manner.
RESULTS
The mean weight of flap edge necrosis was 23.48 +/- 9.5 (mean +/- sem) microg in DMSO group and 126.27 +/- 44.8 microg in control group (p = 0.03). The hospitalization period was 9.6 +/- 0.5 days and 11.8 +/- 0.8 days in DMSO group and control group respectively (p = 0.02). There were no side effects due to DMSO.
CONCLUSION
The application of DMSO reduced skin flap necrosis and improved outcome of surgical flaps.
背景
手术皮瓣坏死是乳房切除术和区域淋巴结清扫术等手术后最常见的问题之一。在这项前瞻性随机研究中，分析了局部应用二甲亚砜（DMSO）对皮瓣活力的影响。
材料与方法
连续66例在乳房切除术中制作皮瓣的乳腺癌患者被随机分为两组。第1组患者的手术皮瓣上应用局部DMSO，第2组患者应用局部生理盐水。在随访期间记录每名患者皮瓣坏死边缘情况，然后以盲法切除并称重。
结果
DMSO组皮瓣边缘坏死的平均重量为23.48±9.5（均值±标准误）微克，对照组为126.27±44.8微克（p = 0.03）。DMSO组和对照组的住院时间分别为9.6±0.5天和11.8±0.8天（p = 0.02）。未发现DMSO引起的副作用。
结论
应用DMSO可减少皮瓣坏死并改善手术皮瓣的预后。
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