Bauernfeind A
Max von Pettenkofer-Institut, Munich, Germany.
J Antimicrob Chemother. 1996 Jul;38 Suppl A:107-15. doi: 10.1093/jac/38.suppl_a.107.
The overall antibiotic susceptibility of Klebsiella pneumoniae isolates collected in 1992 (n = 35) and 1993 (n = 85) was highly variable ranging from 0.8% for amoxycillin to 95.8% for ceftriaxone. On a weight for weight basis, the activity of the compounds decreased in the following sequence: ceftriaxone, cefixime, co-trimoxazole, ciprofloxacin, ofloxacin, cefaclor, amoxycillin/clavulanate, doxycycline, cefuroxime, chloramphenicol, amoxycillin. A small percentage of resistant strains was found for each of the compounds (between 0.8% for ceftriaxone and 12.5% for chloramphenicol) with the exception of amoxycillin which was almost uniformly resistant. There was a trend for the percentage of resistant strains to increase between the two study years for all compounds except for chloramphenicol. Resistance to beta-lactams in France and the USA is likely to have been due to strains producing extended spectrum beta-lactamases.
1992年（n = 35）和1993年（n = 85）收集的肺炎克雷伯菌分离株的总体抗生素敏感性差异很大，阿莫西林的敏感性为0.8%，头孢曲松的敏感性为95.8%。按重量计算，这些化合物的活性按以下顺序降低：头孢曲松、头孢克肟、复方新诺明、环丙沙星、氧氟沙星、头孢克洛、阿莫西林/克拉维酸、强力霉素、头孢呋辛、氯霉素、阿莫西林。除阿莫西林几乎全部耐药外，每种化合物均发现一小部分耐药菌株（头孢曲松为0.8%，氯霉素为12.5%）。除氯霉素外，所有化合物在两个研究年份之间耐药菌株的百分比都有增加的趋势。法国和美国对β-内酰胺类药物的耐药性可能是由于产生超广谱β-内酰胺酶的菌株所致。
