0.5%与1%阿可乐定用于控制氩激光小梁成形术后眼压升高的比较
Apraclonidine 0.5% versus 1% for controlling intraocular pressure elevation after argon laser trabeculoplasty.
作者信息
Threlkeld A B, Assalian A A, Allingham R R, Shields M B
机构信息
Duke University Eye Center, Durham, NC 27710, USA.
出版信息
Ophthalmic Surg Lasers. 1996 Aug;27(8):657-60.
BACKGROUND AND OBJECTIVE
Topical apraclonidine hydrochloride 1% is effective for controlling the intraocular pressure (IOP) rise following argon laser trabeculoplasty (ALT). The 0.5% formulation has recently become available commercially. The objective of this study was to compare the efficacy of these two concentrations for controlling IOP after ALT.
PATIENTS AND METHODS
All patients undergoing ALT were prospectively randomized to receive either 1% or 0.5% apraclonidine 1 hour before and immediately after the laser surgery. IOP was measured before and 2 and 24 hours after the treatment.
RESULTS
No statistically significant difference in mean IOPs was found between the two treatment groups at any time.
CONCLUSION
These data suggest that 0.5% and 1% apraclonidine are equally effective for preventing IOP rise after ALT.
背景与目的
1%的局部用盐酸阿可乐定对控制氩激光小梁成形术（ALT）后眼压（IOP）升高有效。0.5%的制剂最近已上市。本研究的目的是比较这两种浓度在ALT后控制眼压方面的疗效。
患者与方法
所有接受ALT的患者在激光手术前1小时和手术后立即被前瞻性随机分组，分别接受1%或0.5%的阿可乐定。在治疗前、治疗后2小时和24小时测量眼压。
结果
两个治疗组在任何时间的平均眼压均无统计学显著差异。
结论
这些数据表明，0.5%和1%的阿可乐定在预防ALT后眼压升高方面同样有效。
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