Helal M, Messiha N, Amayem A, el-Maghraby A, Elsherif Z, Dabees M
Department of Ophthalmology, El-Maghraby Eye Center, Jeddah, Saudi Arabia.
Ophthalmic Surg Lasers. 1996 Aug;27(8):674-8.
To evaluate the safety and efficacy of two different regimens of mitomycin-C (MMC) application as adjunctive chemotherapy in the treatment of pterygia.
One hundred fifty-six patients underwent pterygium excision using the bare sclera technique. They were randomly assigned to have either 0.1 mg/ml of MMC applied to the bare sclera for 3 minutes intraoperatively, or 0.05-mg/ml drops applied topically for 2 weeks postoperatively. The mean follow-up period was 11 months (range 7 to 17).
Complications with the intraoperative MMC included 5 cases of recurrence (5.75%), 2 cases of superficial punctate keratitis (SPK), and 3 cases of delayed conjunctival wound healing. Topical MMC led to 6 cases of recurrence (6.9%), 5 cases of SPK, 4 cases of delayed conjunctival wound healing, and 2 cases of mild iritis.
A single, intraoperative application of MMC is a simple, effective alternative adjunctive treatment for pterygium.
评估两种不同丝裂霉素 - C（MMC）应用方案作为辅助化疗治疗翼状胬肉的安全性和有效性。
156例患者采用裸巩膜技术行翼状胬肉切除术。他们被随机分为两组，一组在术中将0.1mg/ml的MMC应用于裸巩膜3分钟，另一组在术后局部应用0.05mg/ml滴眼液，持续2周。平均随访期为11个月（范围7至17个月）。
术中应用MMC的并发症包括5例复发（5.75%）、2例浅层点状角膜炎（SPK）和3例结膜伤口延迟愈合。局部应用MMC导致6例复发（6.9%）、5例SPK、4例结膜伤口延迟愈合和2例轻度虹膜炎。
术中单次应用MMC是一种简单、有效的翼状胬肉辅助治疗替代方法。
