Abramo T J, Wiebe R A, Scott S M, Primm P A, McIntyre D, Mydler T
Department of Pediatrics, University of Texas Southwestern Medical Center at Dallas 75235-9063, USA.
Pediatr Emerg Care. 1996 Aug;12(4):252-4. doi: 10.1097/00006565-199608000-00004.
This study was designed to investigate the reliability, safety, and efficacy of measuring end tidal CO2 (ETCO2) in nonintubated pediatric patients presenting to an emergency department (ED) with respiratory emergencies.
DESIGN/SETTING/PATIENTS: Eighty-five children were enrolled in a clinical, prospective, observational study at a university-affiliated children's hospital. Children age four weeks to 15.3 years with upper and lower respiratory diseases were enrolled by convenience sampling over a five-month period.
ETCO2 measurements were obtained on each patient by oral/nasal side-stream capnometry. When a consistent waveform was obtained, the value was compared with a capillary arterial partial pressure of CO2 (CapCO2), oxygen saturation (O2Sat), and clinical observations.
Study patients had a mean ETCO2 reading of 33 mmHg with a standard deviation (SD) of 4.6 mmHg and CapCO2 reading of 36 mmHg with a SD of 4.5 mmHg. Pulmonary findings, final diagnosis, and age did not significantly alter the relationship between CapCO2 and ETCO2. The relationship between CapCO2 and ETCO2 was significant (t = 14.9, P < 0.0001, r = 0.87), with a 95% confidence interval for prediction of +/-5 mmHg.
Dependable ETCO2 values can be obtained using an oral/nasal capnometry circuit, and they consistently correlate with CapCO2 in a pediatric population with upper and lower respiratory diseases. Noninvasive ETCO2 analysis is safe and reliable within the limitations of this study group. Further exploration is necessary to determine the value of this technology in assisting with clinical decisions in the patient with impending respiratory failure.
本研究旨在调查在急诊科(ED)因呼吸急症就诊的非插管儿科患者中测量呼气末二氧化碳(ETCO2)的可靠性、安全性和有效性。
设计/地点/患者:85名儿童参与了一所大学附属医院的临床前瞻性观察研究。在五个月的时间里,通过便利抽样纳入了年龄在4周至15.3岁之间患有上、下呼吸道疾病的儿童。
通过口腔/鼻腔旁流二氧化碳监测仪对每位患者进行ETCO2测量。当获得一致的波形时,将该值与毛细血管动脉血二氧化碳分压(CapCO2)、血氧饱和度(O2Sat)以及临床观察结果进行比较。
研究患者的平均ETCO2读数为33 mmHg,标准差(SD)为4.6 mmHg;CapCO2读数为36 mmHg,SD为4.5 mmHg。肺部检查结果、最终诊断和年龄并未显著改变CapCO2与ETCO2之间的关系。CapCO2与ETCO2之间的关系显著(t = 14.9,P < 0.0001,r = 0.87),预测的95%置信区间为±5 mmHg。
使用口腔/鼻腔二氧化碳监测回路可获得可靠的ETCO2值,并且在患有上、下呼吸道疾病的儿科人群中,这些值与CapCO2始终具有相关性。在本研究组的局限性范围内,无创ETCO2分析是安全可靠的。有必要进一步探索该技术在协助即将发生呼吸衰竭患者的临床决策中的价值。