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癫痫发作的罕见病因。

Unusual cause of seizure.

作者信息

Gouin S, Patel H

机构信息

Division of Emergency Medicine, Hospital for Sick Children, University of Toronto, Ontario, Canada.

出版信息

Pediatr Emerg Care. 1996 Aug;12(4):298-300.

PMID:8858658
Abstract

INTRODUCTION

This case report of camphor ingestion in a 15-month-old child illustrates the potential toxicity of a common household product. Details of the patient presentation are reported along with a review of the literature.

METHODS

Patient information was collected using the records of Poison Control, the Emergency Department, and the Health Records at the Hospital for Sick Children in Toronto, Ontario, Canada. A comprehensive review of the literature was conducted using the MEDLINE database for the time period 1966 to April 1995.

DISCUSSION

Oral ingestion of camphor is unusual, given that these products have both unpleasant taste and texture. This patient ingested 70 ml of an over-the-counter medicated ointment containing 4.73% camphor, 2.6% menthol, and 1.2% eucalyptus oil. While the concentration of camphor in this product is low, an estimated 280 mg/kg of camphor was consumed. With significant ingestion of camphor (> 50 mg/kg), neurologic toxicity is common. In this patient, prolonged generalized tonic-clonic seizure activity was noted approximately two hours post single acute ingestion of camphor. This delay in onset of seizure activity is atypical, as seizures have previously been noted to occur in the 90 minutes following ingestion.

CONCLUSION

Readily available medicated ointments containing camphor have potential for serious or fatal consequences when ingested by children.

摘要

引言

本病例报告讲述了一名15个月大儿童摄入樟脑的情况,说明了一种常见家用产品的潜在毒性。报告了患者的临床表现细节,并对相关文献进行了综述。

方法

通过加拿大安大略省多伦多市病童医院的中毒控制中心记录、急诊科记录和健康记录收集患者信息。使用MEDLINE数据库对1966年至1995年4月期间的文献进行了全面综述。

讨论

鉴于这些产品的味道和质地都不佳,口服樟脑的情况并不常见。该患者摄入了70毫升含有4.73%樟脑、2.6%薄荷醇和1.2%桉叶油的非处方药膏。虽然该产品中樟脑的浓度较低,但估计摄入了280毫克/千克的樟脑。大量摄入樟脑(>50毫克/千克)时,神经毒性很常见。在该患者中,单次急性摄入樟脑约两小时后出现了长时间的全身性强直阵挛性癫痫发作。癫痫发作的延迟发作是非典型的,因为之前曾注意到癫痫发作在摄入后90分钟内发生。

结论

儿童摄入含有樟脑的现成药膏可能会导致严重或致命后果。

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