Henshaw C, Foreman D, Belcher J, Cox J, O'Brien S
Department of Psychiatry, North Staffordshire Hospital, Hartshill, Stoke on Trent, UK.
J Psychosom Obstet Gynaecol. 1996 Mar;17(1):21-8. doi: 10.3109/01674829609025660.
Nine women who had undergone hysterectomy and oophorectomy and who previously suffered from severe premenstrual syndrome (PMS) were given estrogen and progesterone in a naturalistic single-blind paradigm. The 13-item Beck Depression Inventory, Spielberger State Anxiety Inventory, Menstrual Distress Questionnaire and the Daily Ratings Form of the Premenstrual Assessment Form were all given daily. Estradiol and progesterone concentrations were estimated. When results from all subjects were considered together, these measures were not correlated with hormonal status. However, individual subjects showed correlations between some symptom scores and serum progesterone concentrations. We conclude that women diagnosed as having PMS do not respond in a uniform fashion to ovarian hormones. Further quantitative studies are needed to relate these individual differences to the syndrome of PMS.
九名接受过子宫切除术和卵巢切除术且曾患有严重经前综合征（PMS）的女性，在自然主义单盲模式下接受了雌激素和孕激素治疗。每天都要填写13项贝克抑郁量表、斯皮尔伯格状态焦虑量表、月经困扰问卷以及经前评估表的每日评分表。测定雌二醇和孕酮浓度。当综合考虑所有受试者的结果时，这些指标与激素状态并无关联。然而，个别受试者的某些症状评分与血清孕酮浓度之间存在相关性。我们得出结论，被诊断患有PMS的女性对卵巢激素的反应并不一致。需要进一步进行定量研究，以将这些个体差异与PMS综合征联系起来。
