Casson P, Hahn P M, Van Vugt D A, Reid R L
Department of Obstetrics and Gynaecology, Queen's University, Kingston, Ontario, Canada.
Am J Obstet Gynecol. 1990 Jan;162(1):99-105. doi: 10.1016/0002-9378(90)90830-z.
A total of 14 women with severe premenstrual syndrome unresponsive to conservative medical therapy were treated with danazol in doses sufficient to suppress cyclic ovarian steroidogenesis. In each case medical ovarian suppression resulted in complete relief from symptoms. For ongoing symptom relief, each woman elected to undergo bilateral ovariectomy and concomitant hysterectomy. Both medical ovarian suppression and ovariectomy with low-dose conjugated estrogen therapy afforded lasting relief from cyclic symptoms of premenstrual syndrome and a corresponding improvement in overall quality of life. We conclude that cyclic ovarian steroidogenesis is a powerful determinant for the expression of premenstrual symptomatology. Ovariectomy with low-dose estrogen replacement is an effective alternative for the woman with debilitating premenstrual syndrome who does not respond to conventional interventions.
共有14名严重经前综合征且对保守药物治疗无反应的女性接受了达那唑治疗，剂量足以抑制周期性卵巢甾体激素生成。在每种情况下，药物性卵巢抑制均使症状完全缓解。为了持续缓解症状，每位女性选择接受双侧卵巢切除术及同期子宫切除术。药物性卵巢抑制以及卵巢切除联合低剂量结合雌激素治疗均能持久缓解经前综合征的周期性症状，并相应改善整体生活质量。我们得出结论，周期性卵巢甾体激素生成是经前症状表达的一个重要决定因素。对于患有使人衰弱的经前综合征且对传统干预措施无反应的女性，卵巢切除联合低剂量雌激素替代是一种有效的替代方法。
