Elkon K B, Hughes G R, Catovsky D, Clauvel J P, Dumont J, Seligmann M, Tannenbaum H, Esdaile J
Lancet. 1979 Aug 11;2(8137):280-2. doi: 10.1016/s0140-6736(79)90294-0.
In four patients a systemic vasculitis similar to polyarteritis nodosa developed within 2 years of the onset of hairy-cell leukaemia. Arteriographic studies in two patients revealed microaneurysms, and biopsy specimens in three patients revealed a vasculitis affecting medium-sized vessels. Blood neutrophilia and neutrophilic vascular infiltrate were absent. One patient had circulating immune complexes. Two patients responded to corticosteroids alone, one required cyclophosphamide as well as steroids, and one improved without chemotherapy. The association of vasculitis with hairy-cell leukaemia may provide insight into the pathogenesis of arteritis.
4例患者在毛细胞白血病发病后2年内发生了类似于结节性多动脉炎的系统性血管炎。2例患者的动脉造影研究显示有微动脉瘤，3例患者的活检标本显示有累及中等大小血管的血管炎。无血中性粒细胞增多及中性粒细胞性血管浸润。1例患者有循环免疫复合物。2例患者单独使用皮质类固醇有效，1例患者需要环磷酰胺和类固醇，1例患者未行化疗病情改善。血管炎与毛细胞白血病的关联可能有助于深入了解动脉炎的发病机制。
