空肠弯曲菌分离株对氟喹诺酮类和红霉素耐药性的序贯发展

Sequential development of resistance to fluoroquinolones and erythromycin in an isolate of Campylobacter jejuni.

作者信息

Burnens A P, Heitz M, Brodard I, Nicolet J

机构信息

National Reference Laboratory for Foodborne Diseases, University of Berne, Berne, Switzerland.

出版信息

Zentralbl Bakteriol. 1996 Mar;283(3):314-21. doi: 10.1016/s0934-8840(96)80065-x.

DOI:10.1016/s0934-8840(96)80065-x

PMID:8861869

Abstract

A severe episode of Campylobacter jejuni gastroenteritis in a patient with HIV infection was treated with ciprofloxacin and, because of therapeutic failure, subsequently with roxithromycin. After treatment, C. jejuni was again isolated from feces and shown to be resistant to both drugs. We present molecular evidence of the sequential development of both types of resistance in the patient isolate. To our knowledge, this is the first case with documented evidence showing sequential emergence of resistance to fluoroquinolones and erythromycin in a strain of C. jejuni during treatment.

摘要

一名感染HIV的患者发生了严重的空肠弯曲菌胃肠炎，先用环丙沙星治疗，因治疗失败，随后换用罗红霉素治疗。治疗后，再次从粪便中分离出空肠弯曲菌，结果显示该菌对两种药物均耐药。我们提供了该患者分离株中两种耐药性先后发生的分子证据。据我们所知，这是首例有文献记载的空肠弯曲菌菌株在治疗期间先后出现对氟喹诺酮类和红霉素耐药的病例。