Reina J, Borrell N, Serra A
Clinical Microbiology Service, Hospital Son Dureta, Palma de Mallorca, Spain.
Eur J Clin Microbiol Infect Dis. 1992 Dec;11(12):1163-6. doi: 10.1007/BF01961137.
During the period 1987 to 1991 a retrospective study was performed to determine the resistance of thermotolerant Campylobacter species isolated from feces to erythromycin and fluoroquinolones. Of the 672 strains studied, 614 (91.3%) were identified as Campylobacter jejuni and 58 (8.7%) as Campylobacter coli. During the study period the rate of resistance of Campylobacter jejuni to erythromycin remained relatively stable (0.9-3.5%), while resistance of Campylobacter coli to erythromycin emerged later (1989) with much higher rates (14.8-33%). Overall, 11.8% and 10.7% of Campylobacter jejuni strains isolated after 1987 were resistant to nalidixic acid and ciprofloxacin respectively, resistance increasing from 2.3% in 1988 to 32% in 1991. In 1991 the first strains of Campylobacter coli with resistance to these fluoroquinolones were detected (rates 29% and 26% respectively). Of the strains resistant to nalidixic acid, only 10.9% were susceptible to ciprofloxacin.
1987年至1991年期间，开展了一项回顾性研究，以确定从粪便中分离出的耐热弯曲杆菌属菌种对红霉素和氟喹诺酮类药物的耐药性。在所研究的672株菌株中，614株（91.3%）被鉴定为空肠弯曲菌，58株（8.7%）为结肠弯曲菌。在研究期间，空肠弯曲菌对红霉素的耐药率保持相对稳定（0.9%-3.5%），而结肠弯曲菌对红霉素的耐药性出现较晚（1989年），且耐药率高得多（14.8%-33%）。总体而言，1987年后分离出的空肠弯曲菌菌株中，分别有11.8%和10.7%对萘啶酸和环丙沙星耐药，耐药率从1988年的2.3%增至1991年的32%。1991年检测到首批对这些氟喹诺酮类药物耐药的结肠弯曲菌菌株（耐药率分别为29%和26%）。在对萘啶酸耐药的菌株中，仅10.9%对环丙沙星敏感。
