辐照性葡萄膜黑色素瘤：细胞病理学与预后的相关性
Irradiated uveal melanomas: cytopathologic correlation with prognosis.
作者信息
Char D H, Kroll S M, Miller T, Castro J, Quivey J
机构信息
Department of Ophthalmology, University of California, San Francisco, USA.
出版信息
Am J Ophthalmol. 1996 Oct;122(4):509-13. doi: 10.1016/s0002-9394(14)72110-5.
PURPOSE
We analyzed the additional prognostic information from cytopathologic data obtained at the time of uveal melanoma irradiation.
METHODS
Fine-needle aspiration biopsies (FNABs) were performed and reviewed in a masked manner. These data and standard prognostic variables were correlated with survival and local tumor recurrence using Kaplan-Meier and Cox model statistical techniques.
RESULTS
Cytopathologic assessment of cell type added to prognostic accuracy. In 116 patients, the percentage of epithelioid cells on FNAB and ciliary body involvement were most strongly correlated with melanoma-related mortality.
CONCLUSIONS
FNAB data improved our prognostic accuracy in irradiated uveal melanoma patients.
目的
我们分析了葡萄膜黑色素瘤放疗时获得的细胞病理学数据所提供的额外预后信息。
方法
进行细针穿刺活检（FNAB）并采用盲法进行评估。使用Kaplan-Meier和Cox模型统计技术，将这些数据及标准预后变量与生存率和局部肿瘤复发情况进行关联分析。
结果
细胞类型的细胞病理学评估提高了预后准确性。在116例患者中，FNAB上上皮样细胞的百分比和睫状体受累情况与黑色素瘤相关死亡率的相关性最强。
结论
FNAB数据提高了我们对接受放疗的葡萄膜黑色素瘤患者的预后准确性。
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