Thorban S, Roder J D, Pantel K, Siewert J R
Department of Surgery, Technische University Munich, Germany.
Am J Surg. 1996 Sep;172(3):297-8. doi: 10.1016/s0002-9610(96)00103-1.
Epithelial cells in the bone marrow of 42 patients with pancreatic carcinoma were identified immunocytochemically with monoclonal antibodies directed to epithelial cytokeratins. The occurrence of tumor relapse in patients who underwent complete surgical resection was significantly associated with cytokeratin-positivity in bone marrow. The presence of these cells in indicative of an increased disseminative capability of the primary tumor and defines a new category of patients for neoadjuvant therapy.
用针对上皮细胞角蛋白的单克隆抗体对42例胰腺癌患者骨髓中的上皮细胞进行免疫细胞化学鉴定。接受完全手术切除的患者中肿瘤复发的发生与骨髓中细胞角蛋白阳性显著相关。这些细胞的存在表明原发性肿瘤的播散能力增强，并确定了一类新的新辅助治疗患者。
