使用铷-82或氮-13-氨简化用于临床应用的正电子发射断层扫描（PET）冠状动脉血流及血流储备测定。

Coronary flow and flow reserve by PET simplified for clinical applications using rubidium-82 or nitrogen-13-ammonia.

作者信息

Yoshida K, Mullani N, Gould K L

机构信息

Diagnostic Imaging Research, National Institute of Radiological Sciences, Chiba, Japan.

出版信息

J Nucl Med. 1996 Oct;37(10):1701-12.

PMID:8862316

Abstract

UNLABELLED

To validate routine, noninvasive determination of absolute myocardial perfusion and coronary flow reserve (CFR), cardiac PET was performed in animals using a simplified imaging protocol, high-dose dipyridamole and a simplified quantitative algorithm specific for 82Rb and 13N-ammonia.

METHODS

One hundred thirty-five PET scans were obtained in eight dogs after intravenous 13N-ammonia or 82Rb using serial dynamic PET or a simple two-image dataset. A simple flow model using the two-image dataset was developed for each radionuclide to account for varying arterial input function, flow-dependent myocardial extraction and increased permeability surface area (PS) product due to capillary recruitment at high flows not incorporated into previous models. Myocardial perfusion by the simple model was compared to standard, complete, two-compartment kinetic models validated by comparison to electromagnetic flow meter.

RESULTS

For 13N-ammonia, myocardial perfusion by the simple PET model correlated with that by complete compartmental analysis of multiple serial PET images with r = 0.94, slope = 0.96; CFR by compartmental analysis correlated with CFR by electromagnetic flow meter with r = 0.94, slope = 0.97. For 82Rb, myocardial perfusion determined by the simple model correlated with that determined by complete compartmental analysis of multiple serial PET images with r = 0.98, slope = 1.06; CFR determined by compartmental analysis correlated with CFR by electromagnetic flow meter with r = 0.88, slope = 1.13.

CONCLUSION

A simplified PET protocol using 13N-ammonia or 82Rb and simple flow models provide noninvasive measurement of CFR up to six times baseline flow throughout the heart and diagnostic image quality for routine clinical application.

摘要

未标注

为验证常规、非侵入性测定绝对心肌灌注和冠状动脉血流储备（CFR），在动物中使用简化成像方案、高剂量双嘧达莫以及针对82Rb和13N-氨的简化定量算法进行了心脏PET检查。

方法

对8只狗静脉注射13N-氨或82Rb后，使用连续动态PET或简单的双图像数据集获得了135次PET扫描。针对每种放射性核素开发了一个使用双图像数据集的简单血流模型，以考虑不同的动脉输入函数、血流依赖性心肌摄取以及由于高血流时毛细血管募集导致的通透性表面积（PS）乘积增加，而之前的模型未纳入这些因素。将简单模型测定的心肌灌注与通过与电磁流量计比较验证的标准、完整的双室动力学模型进行比较。

结果

对于13N-氨，简单PET模型测定的心肌灌注与对多个连续PET图像进行完整房室分析测定的心肌灌注相关，r = 0.94，斜率 = 0.96；房室分析测定的CFR与电磁流量计测定的CFR相关，r = 0.94，斜率 = 0.97。对于82Rb，简单模型测定的心肌灌注与对多个连续PET图像进行完整房室分析测定的心肌灌注相关，r = 0.98，斜率 = 1.06；房室分析测定的CFR与电磁流量计测定的CFR相关，r = 0.88，斜率 = 1.13。