Kubová H, Haugvicová R, Mares P
Institute of Physiology, Academy of Sciences, Czech Republic, Prague.
Biol Neonate. 1996;69(6):405-12. doi: 10.1159/000244338.
The possible anticonvulsant action of baclofen, a GABAB (gamma-aminobutyric acid) receptor agonist, was studied using two types of motor seizures (minimal, clonic and generalized tonicoclonic) elicited by pentylenetetrazol in adult rats and rat pups, 7, 12, 18, and 25 days old. If baclofen was administered intraperitoneally (only in 12- and 25-day-old rats), no effect could be observed in 25-day-old animals. In 12-day-old rats, only the 12-mg/kg dose led to a prolongation of the generalized tonicoclonic seizure latency. Subcutaneous administration of baclofen (3, 6, or 12 mg/kg 30 min before subcutaneous pentylenetetrazol injection) led to a moderate action against the tonic phase of generalized tonicoclonic seizures: the tonic phase of hind limbs was significantly suppressed in all age groups, whereas total suppression of the tonic phase was only outlined. Minimal, i.e., clonic, seizures with preserved righting ability were not influenced by baclofen. The conclusion could be made that the anticonvulsant action of baclofen is dependent on the model of seizures used and that there is no change of baclofen action against pentylenetetrazol-induced seizures during postnatal development in rats.
使用戊四氮在成年大鼠以及7日龄、12日龄、18日龄和25日龄的幼鼠中引发的两种运动性癫痫发作（轻微发作、阵挛性发作和全身性强直阵挛性发作），对γ-氨基丁酸B（GABAB）受体激动剂巴氯芬可能的抗惊厥作用进行了研究。如果腹腔注射巴氯芬（仅在12日龄和25日龄的大鼠中进行），在25日龄的动物中未观察到任何效果。在12日龄的大鼠中，只有12毫克/千克的剂量导致全身性强直阵挛性发作潜伏期延长。皮下注射巴氯芬（在皮下注射戊四氮前30分钟给予3、6或12毫克/千克）对全身性强直阵挛性发作的强直期有中等程度的作用：所有年龄组后肢的强直期均受到显著抑制，而强直期的完全抑制仅初现端倪。具有翻正能力的轻微发作，即阵挛性发作，不受巴氯芬影响。可以得出结论，巴氯芬的抗惊厥作用取决于所使用的癫痫发作模型，并且在大鼠出生后的发育过程中，巴氯芬对戊四氮诱导的癫痫发作的作用没有变化。
