Stanková L, Kozuchová A, Mares P
Institute of Physiology, Academy of Sciences of the Czech Republic, Prague.
Physiol Res. 1997;46(1):47-52.
The action of progabide against motor seizures elicited by pentylenetetrazol was studied in 7-, 12-, 18-, 25-day-old and adult rats. Progabide (dissolved in dimethylsulfoxide) was injected in doses from 12.5 to 150 mg/kg i.p. 30 min before pentylenetetrazol. Minimal seizures were not affected by solvent or progabide pretreatment. The action of progabide against major, i.e. generalized tonic-clonic seizures, changed with age: adult rats exhibited a tendency to suppression of whole major seizures, whereas specific suppression of the tonic phase was observed in rat pups during the first three weeks of life. The only effect seen in 25-day-old animals was prolongation of the latency of major seizures after the highest dose of progabide.
在7日龄、12日龄、18日龄、25日龄的大鼠及成年大鼠中研究了普罗加比对抗戊四氮引发的运动性癫痫发作的作用。普罗加比（溶于二甲基亚砜）在戊四氮注射前30分钟腹腔注射，剂量为12.5至150毫克/千克。轻微癫痫发作不受溶剂或普罗加比预处理的影响。普罗加比对严重癫痫发作（即全身性强直阵挛性发作）的作用随年龄而变化：成年大鼠表现出抑制整个严重癫痫发作的趋势，而在出生后前三周的幼鼠中观察到对强直期的特异性抑制。在25日龄动物中观察到的唯一作用是在给予最高剂量的普罗加比后，严重癫痫发作的潜伏期延长。
