Iles S A, Evans E P
J Embryol Exp Morphol. 1977 Apr;38:77-91.
Karotype and capacity for differentiation were determined in four transplantable teratomas, and their embryoid bodies, derived from C3H mouse embryos. An apparently normal karyotype was retained by one tumour and one subline that were able to differentiate into a wide range of tissues, but some chromosomal alterations were found in the two tumours and one subline that showed almost identical restrictions in their capacity for differentiation. Trisomy for chromosome 11 was shared by all three restricted tumours; two of the tumours had similar length changes in the same two chromosome (1 and 14) while the third was generally trisomic for four other chromosomes.
对来自C3H小鼠胚胎的4个可移植畸胎瘤及其胚体进行了核型和分化能力测定。一个肿瘤及其一个亚系保留了明显正常的核型，它们能够分化为多种组织，但在另外两个肿瘤及其一个亚系中发现了一些染色体改变，这些肿瘤在分化能力上表现出几乎相同的限制。所有三个受限肿瘤都存在11号染色体三体；其中两个肿瘤在相同的两条染色体（1号和14号）上有相似的长度变化，而第三个肿瘤在另外四条染色体上普遍为三体。
