Mantzoros C S, Georgiadis E I, Evangelopoulou K, Katsilambros N
Division of Endocrinology, Beth Israel Hospital, Boston, MA 02215, USA.
Epidemiology. 1996 Sep;7(5):513-6.
To evaluate the relative importance of androgen and insulin concentrations in predicting body fat distribution, we measured their association with waist-hip ratio in a sample of 151 consecutively enrolled healthy premenopausal women age 18-24 years, after controlling for potential confounding variables. Dehydroepiandrosterone sulfate (DHEAS) and total testosterone were independently associated with waist-hip ratio, whereas insulin and free testosterone did not appear to play a role of comparable importance. Differences in concentrations of circulating DHEAS and total testosterone are independently associated with the waist-hip ratio in premenopausal women, providing epidemiologic support to the "neuroendocrine dysregulation" hypothesis for the pathogenesis of central obesity.
为评估雄激素和胰岛素浓度在预测体脂分布中的相对重要性，我们在151名年龄在18 - 24岁、连续入组的健康绝经前女性样本中，在控制了潜在混杂变量后，测量了它们与腰臀比的关联。硫酸脱氢表雄酮（DHEAS）和总睾酮与腰臀比独立相关，而胰岛素和游离睾酮似乎未发挥同等重要的作用。循环中DHEAS和总睾酮浓度的差异与绝经前女性的腰臀比独立相关，为中心性肥胖发病机制的“神经内分泌失调”假说提供了流行病学支持。
