Vinceti M, Guidetti D, Pinotti M, Rovesti S, Merlin M, Vescovi L, Bergomi M, Vivoli G
Department of Biomedical Sciences, University of Modena, Italy.
Epidemiology. 1996 Sep;7(5):529-32.
We examined 9 years' incidence of amyotrophic lateral sclerosis, a disease previously associated with a high-selenium environment, in a cohort of 5,182 residents of Reggio Emilia, Italy. This cohort had accidentally been exposed to drinking water with high selenium content. Four cases were diagnosed during the follow-up. Using the remainder of the municipal population as the reference group, the standardized incidence ratio was 4.22 (95% confidence interval = 1.15-10.80). The standardized incidence ratio was higher after limiting the analysis to the subcohort with the longest ascertainable exposure period. The findings appear to confirm a causal association between overexposure to environmental selenium and amyotrophic lateral sclerosis.
我们在意大利雷焦艾米利亚的5182名居民队列中，研究了肌萎缩侧索硬化症（一种先前与高硒环境相关的疾病）的9年发病率。该队列意外接触了高硒含量的饮用水。随访期间诊断出4例病例。以该市其余人口作为参照组，标准化发病率为4.22（95%置信区间=1.15 - 10.80）。将分析局限于可确定最长暴露期的亚队列后，标准化发病率更高。这些发现似乎证实了环境硒过度暴露与肌萎缩侧索硬化症之间的因果关联。
