Aimard G, Bady B, Boisson D, Trouillas P, Devic M
Rev Neurol (Paris). 1976 Aug;132(8):563-6.
Twenty-five cases of amyotrophic lateral sclerosis occurring before the age of 40, collected between 1963 and 1973 in the Neurological Hospital, Lyons, have prompted the authors to make the following observations. -The incidence of disease seems to have been on the increase during this period both in absolute terms and relatively speaking (relative to the total number of patients hospitalized and to the total number of patients hospitalized for amyotrophic lateral sclerosis after the age of forty). -The 25 cases involved mostly women--the opposite of what was found in cases of amyotrophic lateral sclerosis occurring after forty. -Only one was possibly familial. -The onset is mostly with purely pyramidal features or of the topographically circumscribed peripheral type. Development appears to take longer than the average for amyotrophic lateral sclerosis. It would be worth while confirming these findings by analysis of other similar groups.
1963年至1973年间在里昂神经医院收集的25例40岁之前发病的肌萎缩侧索硬化症病例促使作者做出如下观察。——在此期间，该疾病的发病率无论从绝对数量还是相对比例来看（相对于住院患者总数以及40岁以后因肌萎缩侧索硬化症住院的患者总数）似乎都在上升。——这25例病例大多为女性，这与40岁以后发病的肌萎缩侧索硬化症病例情况相反。——只有1例可能是家族性的。——发病大多表现为纯粹的锥体束征或局限于特定部位的周围型。其发展过程似乎比肌萎缩侧索硬化症的平均病程要长。通过分析其他类似病例组来证实这些发现将是很有价值的。
