Rosol T J, Capen C C
Department of Veterinary Biosciences, Ohio State University, Columbus, USA.
Vet Clin North Am Small Anim Pract. 1996 Sep;26(5):1155-84. doi: 10.1016/s0195-5616(96)50060-4.
The goal of this article is to summarize key features of calcium, phosphorus, and magnesium pathophysiology and highlight some of the recent scientific accomplishments in these fields. The area of calcium physiology has been especially active due to the discovery of a new calcium-regulating hormone, parathyroid hormone-related protein, cloning of the parathyroid hormone receptor and identification of a cell membrane receptor for ionized calcium. Advances have also been made in understanding the role of phosphorus and the active form of vitamin D, 1,25-dihydroxyvitamin D in the pathogenesis of secondary hyperparathyroidism in patients with chronic renal failure. The role of magnesium in many pathologic processes, including cardiac disease, is gaining a heightened appreciation due to its function in many metabolic processes and the development of techniques to measure ionized magnesium concentrations.
本文的目的是总结钙、磷和镁病理生理学的关键特征，并强调这些领域最近的一些科学成就。由于发现了一种新的钙调节激素——甲状旁腺激素相关蛋白，克隆了甲状旁腺激素受体，并鉴定出离子钙的细胞膜受体，钙生理学领域一直特别活跃。在理解磷以及维生素D的活性形式1,25-二羟维生素D在慢性肾衰竭患者继发性甲状旁腺功能亢进发病机制中的作用方面也取得了进展。镁在包括心脏病在内的许多病理过程中的作用，由于其在许多代谢过程中的功能以及测量离子镁浓度技术的发展而日益受到重视。
