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用于治疗顽固性急迫性尿失禁的改良英格曼-松德贝里膀胱去神经支配手术

Modified Ingelman-Sundberg bladder denervation procedure for intractable urge incontinence.

作者信息

Cespedes R D, Cross C A, McGuire E J

机构信息

Divison of Urology, University of Texas Medical School at Houston, USA.

出版信息

J Urol. 1996 Nov;156(5):1744-7.

PMID:8863585
Abstract

PURPOSE

We determined the efficacy of the modified Ingelman-Sundberg procedure in women with urge incontinence and intractable detrusor instability.

MATERIALS AND METHODS

Women with urge incontinence and detrusor instability, in whom medical and behavioral therapy failed, received transvaginal local anesthesia to block the terminal pelvic nerve branches to the bladder. Urge incontinence resolved temporarily in 25 patients, who subsequently underwent modified Ingelman-Sundberg transvaginal bladder denervation. All patients underwent preoperative urodynamic evaluation but documented detrusor instability was not a requirement for surgery.

RESULTS

Of the patients 16 (64%) were cured of urge incontinence with substantial relief of detrusor instability, 2 (8%) had temporary improvement and 7 (28%) had no change. No patient who was cured required further surgery (mean followup 14.8 months, range 4 to 30). Use of anticholinergic agents also decreased dramatically: 5 patients used no, 9 used 1 and 2 used 2 medications. Detrusor instability was documented in 44% of the patients and was not predictive of operative outcome. There were no major complications of the procedure. Operative time was approximately 15 minutes.

CONCLUSIONS

In patients with urge incontinence and medically refractory detrusor instability, with few simple choices for treatment, the modified Ingelman-Sundberg procedure is an excellent surgical option that yields good results with minimal morbidity.

摘要

目的

我们确定了改良英格曼-松德贝里手术对尿急失禁和顽固性逼尿肌不稳定女性患者的疗效。

材料与方法

尿急失禁和逼尿肌不稳定且药物及行为治疗无效的女性患者,接受经阴道局部麻醉以阻断膀胱的终末盆神经分支。25例患者尿急失禁暂时缓解,随后接受改良英格曼-松德贝里经阴道膀胱去神经支配术。所有患者术前行尿动力学评估,但记录有逼尿肌不稳定并非手术的必要条件。

结果

患者中,16例(64%)尿急失禁治愈,逼尿肌不稳定明显缓解;2例(8%)有暂时改善;7例(28%)无变化。治愈的患者均无需进一步手术(平均随访14.8个月,范围4至30个月)。抗胆碱能药物的使用也显著减少:5例患者不用药,9例用1种,2例用2种药物。44%的患者记录有逼尿肌不稳定,且其不能预测手术结果。该手术无重大并发症。手术时间约15分钟。

结论

对于尿急失禁和药物治疗难治性逼尿肌不稳定的患者,治疗选择有限,改良英格曼-松德贝里手术是一种极佳的手术选择,效果良好且发病率极低。

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