病毒诱导的慢性肝病中的肝移植

Liver transplantation in virus-induced chronic liver disease.

作者信息

Colantoni A, De Maria N, Fagiuoli S, Van Thiel D H

机构信息

Chandler Medical Center, University of Kentucky, Lexington 40536, USA.

出版信息

Baillieres Clin Gastroenterol. 1996 Jul;10(2):375-88. doi: 10.1016/s0950-3528(96)90011-1.

DOI:10.1016/s0950-3528(96)90011-1

PMID:8864038

Abstract

The current status of liver transplantation (OLTx) for chronic viral hepatitis is reviewed. The major issues addressed include the rate of recurrence of disease, its severity and natural history, and the potential for therapy. These issues vary markedly for each type of viral hepatitis. The development of new antiviral agents for clinical use may change the current restriction on liver transplantation for hepatitis B virus (HBV)-related liver disease such that it begins to challenge hepatitis C virus (HCV) as the principal indication for OLTx world-wide.

摘要

本文综述了慢性病毒性肝炎肝移植（OLTx）的现状。所探讨的主要问题包括疾病的复发率、严重程度和自然史，以及治疗的可能性。这些问题在每种病毒性肝炎中差异显著。用于临床的新型抗病毒药物的研发可能会改变目前对乙型肝炎病毒（HBV）相关肝病肝移植的限制，使其开始挑战丙型肝炎病毒（HCV），成为全球肝移植的主要适应证。