Vanderwolf C H, Baker G B
Department of Psychology, University of Western Ontario, London, Canada.
Behav Brain Res. 1996 Aug;78(2):225-34. doi: 10.1016/0166-4328(95)00253-7.
Local injection of 6-hydroxydopamine in the locus coeruleus resulted in a 90% depletion of noradrenaline (NA) in the cerebral cortex as assessed by high-pressure liquid chromatography. This NA depletion had no effect on scopolamine-resistant hippocampal rhythmical slow activity and only an occasional effect on scopolamine-resistant neocortical low voltage fast activity. However, NE depletion resulted in a slight deficit in a behavioral swim-to-platform test and increased the deficit produced on the test by systemic treatment with scopolamine. Large surgical lesions of the medial thalamus or hippocampal formation plus posterior neocortex greatly increased the behavioral deficit produced by scopolamine. It is concluded that ascending noradrenergic projections play only a modest and possibly indirect role in the control of electrocortical activation and that a number of different brain lesions increase the behavioral impairment produced by central muscarinic blockade.
通过高压液相色谱法评估，在蓝斑局部注射6-羟基多巴胺导致大脑皮质中去甲肾上腺素（NA）耗竭90%。这种NA耗竭对东莨菪碱抵抗性海马节律性慢活动没有影响，对东莨菪碱抵抗性新皮质低电压快活动仅有偶尔的影响。然而，去甲肾上腺素（NE）耗竭在行为性游泳至平台试验中导致轻微缺陷，并增加了东莨菪碱全身治疗在该试验中产生的缺陷。内侧丘脑或海马结构加后新皮质的大型手术损伤极大地增加了东莨菪碱产生的行为缺陷。得出的结论是，上行去甲肾上腺素能投射在控制皮质电活动中仅起适度且可能是间接的作用，并且多种不同的脑损伤会增加中枢毒蕈碱阻断产生的行为损害。
