Lin C N, Lu C M, Lin H C, Fang S C, Shieh B J, Hsu M F, Wang J P, Ko F N, Teng C M
School of Pharmacy, Kaohsiung Medical College, Taiwan, Republic of China.
J Nat Prod. 1996 Sep;59(9):834-8. doi: 10.1021/np960376j.
Sixteen constituents from Formosan Moraceous plants were tested for their antiplatelet activities in rabbit platelet suspension and human platelet-rich plasma. Cycloartocarpin A, cycloheterophyllin, broussochalcone A, kazinol A, broussoaurone A, and broussoflavonol F showed strong inhibition of arachidonic acid (AA)-induced platelet aggregation. Of the compounds tested, broussochalcone A exhibited the most potent inhibition of platelet aggregation induced by AA (IC50 = 6.8 microM). The antiplatelet effects of cycloheterophyllin, broussochalcone A, kazinol B, broussoaurone A, and broussoflavonol F are partially due to an inhibitory effect on cyclooxygenase.
对来自台湾桑科植物的16种成分在兔血小板悬浮液和人富血小板血浆中进行了抗血小板活性测试。环阿尔廷卡宾A、环异叶林、毛果算盘子查耳酮A、卡齐诺醇A、毛果算盘子黄酮A和毛果算盘子黄酮F对花生四烯酸（AA）诱导的血小板聚集表现出强烈抑制作用。在所测试的化合物中，毛果算盘子查耳酮A对AA诱导的血小板聚集表现出最有效的抑制作用（IC50 = 6.8 microM）。环异叶林、毛果算盘子查耳酮A、卡齐诺醇B、毛果算盘子黄酮A和毛果算盘子黄酮F的抗血小板作用部分归因于对环氧化酶的抑制作用。
