从泰氏红厚壳乳胶中分离出的香豆素索拉曲利介导的对人免疫缺陷病毒1型逆转录酶的特异性抑制作用。
Specific inhibition of human immunodeficiency virus type 1 reverse transcriptase mediated by soulattrolide, a coumarin isolated from the latex of calophyllum teysmannii.
作者信息
Pengsuparp T, Serit M, Hughes S H, Soejarto D D, Pezzuto J M
机构信息
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.
出版信息
J Nat Prod. 1996 Sep;59(9):839-42. doi: 10.1021/np960399y.
PMID:8864237
Abstract
Soulattrolide (1), a coumarin isolated from Calophyllum teysmannii latex, was found to be a potent inhibitor of HIV-1 reverse transcriptase (RT) with an IC50 of 0.34 microM. Inhibition was remarkably specific, with no appreciable activity being observed toward HIV-2 RT, AMV RT, RNA polymerase, or DNA polymerases alpha or beta.
摘要
索拉曲利德（1）是从泰氏红厚壳乳汁中分离出的一种香豆素，被发现是一种有效的HIV-1逆转录酶（RT）抑制剂，IC50为0.34微摩尔。抑制作用具有显著的特异性，对HIV-2 RT、禽成髓细胞瘤病毒逆转录酶、RNA聚合酶或DNA聚合酶α或β未观察到明显活性。
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