用于治疗人类免疫缺陷病毒的药用植物。
Medicinal Plants Used in the Treatment of Human Immunodeficiency Virus.
机构信息
Medical Ethics and Law Research Center, Shahid Beheshti University of Medical Sciences, 88777539 Tehran, Iran.
Student Research Committee, Shahid Beheshti University of Medical Sciences, 22439789 Tehran, Iran.
出版信息
Int J Mol Sci. 2018 May 14;19(5):1459. doi: 10.3390/ijms19051459.
Since the beginning of the epidemic, human immunodeficiency virus (HIV) has infected around 70 million people worldwide, most of whom reside is sub-Saharan Africa. There have been very promising developments in the treatment of HIV with anti-retroviral drug cocktails. However, drug resistance to anti-HIV drugs is emerging, and many people infected with HIV have adverse reactions or do not have ready access to currently available HIV chemotherapies. Thus, there is a need to discover new anti-HIV agents to supplement our current arsenal of anti-HIV drugs and to provide therapeutic options for populations with limited resources or access to currently efficacious chemotherapies. Plant-derived natural products continue to serve as a reservoir for the discovery of new medicines, including anti-HIV agents. This review presents a survey of plants that have shown anti-HIV activity, both in vitro and in vivo.
自疫情开始以来，全球约有 7000 万人感染了人类免疫缺陷病毒（HIV），其中大多数人居住在撒哈拉以南非洲地区。使用抗逆转录病毒药物鸡尾酒疗法治疗 HIV 方面取得了非常有希望的进展。然而，抗 HIV 药物的耐药性正在出现，许多感染 HIV 的人对现有抗 HIV 化疗药物有不良反应或无法获得。因此，有必要发现新的抗 HIV 药物来补充我们目前的抗 HIV 药物库，并为资源有限或无法获得目前有效化疗药物的人群提供治疗选择。植物来源的天然产物仍然是发现新药的宝库，包括抗 HIV 药物。本综述介绍了具有抗 HIV 活性的植物，包括体外和体内活性。
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