Lanng S
CF Center Copenhagen, Department of Paediatrics, Rigshospitalet, Denmark.
Eur J Gastroenterol Hepatol. 1996 Aug;8(8):744-7.
Diabetes mellitus in cystic fibrosis (CF-DM) is increasingly prevalent with age, develops insidiously and is characterized by insulinopenia, normal insulin sensitivity, increased insulin clearance rate and concomitant exocrine pancreatic insufficiency. Since CF-DM impairs overall CF clinical status, including lung function, and may result in late diabetic complications, the condition should be screened for by annual oral glucose tolerance tests (OGTTs) from the age of 10 years, and be treated with insulin from the time of diagnosis of CF-DM.
囊性纤维化相关性糖尿病（CF-DM）的患病率随年龄增长而日益增加，起病隐匿，其特征为胰岛素缺乏、胰岛素敏感性正常、胰岛素清除率增加以及伴有外分泌性胰腺功能不全。由于CF-DM会损害包括肺功能在内的整体CF临床状况，并可能导致晚期糖尿病并发症，因此应从10岁起每年通过口服葡萄糖耐量试验（OGTT）进行筛查，一旦诊断为CF-DM即开始使用胰岛素治疗。
