Thollander M, Hellström P M, Svensson T H, Gazelius B
Department of Medicine, Karolinska Hospital, Stockholm, Sweden.
Eur J Gastroenterol Hepatol. 1996 Aug;8(8):777-85.
To evaluate local intestinal blood flow and its relationship to fasting gut motility in humans.
Regional laser Doppler flowmetry (LDF) was carried out for 8 h in 14 tasted volunteers. LDF measured as perfusion units (PU) was performed using two single-fibre microprobes attached to a small intestinal manometry tube, which monitored migrating motor complexes (MMCs). Luminal pressures of small intestine were registered in analogue and digital recordings.
During phase 1 of MMC, PU values of 65 (33-95) and 37 (20-100) in proximal and distal duodenum were measured. During phase 2, PU values increased by 17% and 38%, respectively (each P < 0.001). At phase 3 of MMC, corresponding PU values increased by 363% and 443% (each P < 0.001) and remained at high levels until termination of phase 3. During phase 3 there was aboral propagation of LDF activity. Computerized recordings allowed detailed analysis of relationships between LDF pattern and luminal pressures. At pressures below 48 (42-54) mmHg, individual LDF cycles and contraction cycles were phase displaced at 180 degrees, indicating low perfusion during contractions. When pressures exceeded 48 (42-54) mmHg, a decrease in PU was registered and the cycling pattern of LDF was abolished. Then, as luminal pressure decreased below 33 (25-41) mmHg, PU increased by 246%.
Our findings show a relationship between fasting motility and blood flow in the human gut, in which the blood flow exhibited a pattern similar to phase 1, 2 and 3 of the MMC.
评估人体局部肠道血流及其与空腹肠道运动的关系。
对14名受试志愿者进行了8小时的区域激光多普勒血流测定（LDF）。使用连接到小肠测压管的两个单纤维微型探头进行以灌注单位（PU）衡量的LDF测量，该测压管监测移行性运动复合波（MMC）。小肠腔内压力以模拟和数字记录的方式进行登记。
在MMC的第1期，测得十二指肠近端和远端的PU值分别为65（33 - 95）和37（20 - 100）。在第2期，PU值分别增加了17%和38%（均P < 0.001）。在MMC的第3期，相应的PU值分别增加了363%和443%（均P < 0.001），并在第3期结束前一直保持在高水平。在第3期，LDF活动出现向口传播。计算机记录允许对LDF模式与腔内压力之间的关系进行详细分析。当压力低于48（42 - 54）mmHg时，个体LDF周期和收缩周期相位相差180度，表明收缩期间灌注较低。当压力超过48（42 - 54）mmHg时，记录到PU下降，LDF的循环模式被消除。然后，当腔内压力降至33（25 - 41）mmHg以下时，PU增加了246%。
我们的研究结果表明，人体肠道空腹运动与血流之间存在关联，其中血流呈现出与MMC的第1、2和3期相似的模式。
