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小脑毛细胞型星形细胞瘤完全手术切除后罕见的早期复发。病例报告及文献复习

Unusual early recurrence of a cerebellar pilocytic astrocytoma following complete surgical resection. Case report and review of the literature.

作者信息

Sioutos P J, Hamilton A J, Narotam P K, Weinand M E

机构信息

Department of Surgery, University of Arizona Health Sciences Center, Tucson, USA.

出版信息

J Neurooncol. 1996 Oct;30(1):47-54. doi: 10.1007/BF00177442.

Abstract

Pilocytic cerebellar astrocytomas are usually benign tumors with generally an excellent prognosis following complete surgical resection. The goal of surgery is total resection to minimize the risk of recurrence. In this case report, a 5-year old boy who had undergone total resection of a posterior fossa pilocytic cerebellar astrocytoma (as documented by a contrast-enhanced computed tomography (CT) scan within 24 hours following surgery), developed a massive recurrence of the tumor within four months. Both the initial histology and the sections examined after the second resection revealed features typical for a pilocytic astrocytoma with no suspicion of malignancy. This case is unusual in that it is contrary to other reports suggesting that CT-documented complete surgical resection of pilocytic astrocytomas is without recurrence, and suggests the need for vigilant radiographic and clinical follow-up of these patients even if apparent complete resection of the tumor has been achieved.

摘要

毛细胞型小脑星形细胞瘤通常是良性肿瘤,完全手术切除后预后一般极佳。手术的目标是完全切除,以将复发风险降至最低。在本病例报告中,一名5岁男孩接受了后颅窝毛细胞型小脑星形细胞瘤的完全切除(术后24小时内的增强计算机断层扫描(CT)证实),但在四个月内肿瘤出现大量复发。初次组织学检查以及二次切除后的切片检查均显示为毛细胞型星形细胞瘤的典型特征,未怀疑有恶性病变。该病例不同寻常之处在于,与其他报告相反,那些报告表明CT记录的毛细胞型星形细胞瘤完全手术切除后不会复发,这表明即使已实现肿瘤的明显完全切除,对这些患者仍需进行警惕的影像学和临床随访。

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