Hughes D A, Smith G C, Davidson J E, Murphy A V, Beattie T J
Royal Hospital For Sick Children, Glasgow, Scotland, UK.
Pediatr Nephrol. 1996 Aug;10(4):445-7. doi: 10.1007/s004670050136.
Neutrophil-mediated tissue damage has been implicated in the pathogenesis of diarrhoea-associated haemolytic uraemic syndrome (D+ HUS). This study evaluates priming and activation of the neutrophil oxidative burst in D+ HUS using chemiluminescent techniques. Peripheral blood neutrophils from 11 children with acute D+ HUS were examined. No difference was found in the oxidative burst of neutrophils from patients and controls. Serum elastase levels were measured in 8 patients and found to be significantly elevated. Although elastase results suggest neutrophil activation, chemiluminescence studies do not confirm this in the peripheral blood neutrophil. This does not support a significant role for circulating agents in priming and activating the peripheral blood neutrophil.
中性粒细胞介导的组织损伤与腹泻相关的溶血尿毒综合征（D+HUS）的发病机制有关。本研究使用化学发光技术评估D+HUS中中性粒细胞氧化爆发的启动和激活情况。对11名急性D+HUS患儿的外周血中性粒细胞进行了检查。患者和对照组中性粒细胞的氧化爆发未发现差异。对8名患者的血清弹性蛋白酶水平进行了测量，发现其显著升高。尽管弹性蛋白酶结果提示中性粒细胞激活，但化学发光研究并未在外周血中性粒细胞中证实这一点。这并不支持循环因子在启动和激活外周血中性粒细胞中起重要作用。
