Arkwright P D, Clark G
Department of Paediatrics, Guy's Hospital, London, UK.
Pediatr Nephrol. 1996 Aug;10(4):509-10. doi: 10.1007/s004670050152.
Nephrotic syndrome presenting in the 1st year of life is often associated with a very poor prognosis for normal renal function. A small proportion of patients, particularly boys, presenting after the first 3 months of life with idiopathic-type, steroid-sensitive nephrosis, have a much better prognosis and may achieve sustained remission. We describe three boys with infantile idiopathic nephrotic syndrome of the mesangial proliferative glomerulonephritis type who went into complete remission. The patients, their first-degree relatives or both suffered from atopy (eczema, asthma or hayfever). This is the first report linking infantile nephrotic syndrome and atopy. The literature linking idiopathic nephrotic syndrome and atopy is reviewed, and the implications of our findings discussed.
1岁时出现的肾病综合征通常与正常肾功能的预后极差相关。一小部分患者，尤其是男孩，在出生后3个月后出现特发性、类固醇敏感性肾病，其预后要好得多，可能实现持续缓解。我们描述了3例系膜增生性肾小球肾炎型婴儿特发性肾病综合征完全缓解的男孩。这些患者、他们的一级亲属或两者都患有特应性疾病（湿疹、哮喘或花粉热）。这是将婴儿肾病综合征与特应性疾病联系起来的首份报告。本文对将特发性肾病综合征与特应性疾病联系起来的文献进行了综述，并讨论了我们研究结果的意义。
