Meadow S R, Sarsfield J K
Arch Dis Child. 1981 Jul;56(7):509-16. doi: 10.1136/adc.56.7.509.
Eighty-four children with steroid-responsive nephrotic syndrome who had been shown to have, or were believed to have, minimal change histology were investigated to study the relationship between steroid-responsive nephrotic syndrome and allergy. They were found to have a greater incidence of the standard atopic disorders--asthma, eczema, recurrent urticaria, and hay fever. Their 1st-degree relatives had an increased incidence of these atopic disorders too. A nasal discharge was a frequent precursor or an accompaniment of nephrotic syndrome, but an overt atrophic disorder at the same time was rare. Such disorders, related to relapse, occurred in only 5 children; in none was it a consistent or recurrent happening at the time of each relapse. No example of pollen hypersensitivity nephrotic syndrome was found, and no particular allergen could be identified with certainty as responsible for a child's nephrotic syndrome. No association was found between the time of relapse and the season of the year, or the season in which the child was born. Children with nephrotic syndrome had a greater incidence of positive skin tests to common antigens, the comparative frequency of positive reactions to different antigens being similar to that found in children with asthma, although the total frequency was about half that of children with asthma. Despite the increased incidence of clinical features of atopy, measures to reduce the frequency of relapse of nephrotic syndrome by allergen avoidance, the use of sodium cromoglycate, and the use of a new oral antiallergic drug were unsuccessful.
对84名患有类固醇反应性肾病综合征的儿童进行了研究，这些儿童已被证实或被认为具有微小病变组织学，以探讨类固醇反应性肾病综合征与过敏之间的关系。他们被发现患有标准特应性疾病（哮喘、湿疹、复发性荨麻疹和花粉症）的发生率更高。他们的一级亲属患这些特应性疾病的发生率也有所增加。流涕是肾病综合征常见的先兆或伴随症状，但同时明显的萎缩性疾病很少见。与复发相关的此类疾病仅在5名儿童中出现；在每次复发时，均未出现持续或反复发生的情况。未发现花粉过敏性肾病综合征的病例，也无法确定任何特定过敏原是导致儿童肾病综合征的原因。未发现复发时间与一年中的季节或儿童出生季节之间存在关联。肾病综合征患儿对常见抗原的皮肤试验阳性率更高，对不同抗原的阳性反应相对频率与哮喘患儿相似，尽管总频率约为哮喘患儿的一半。尽管特应性临床特征的发生率有所增加，但通过避免接触过敏原、使用色甘酸钠和一种新型口服抗过敏药物来降低肾病综合征复发频率的措施均未成功。
