Yuasa J, Kishi R, Harabuchi I, Eguchi T, Arata Y, Fujita S, Miyake H
Department of Public Health, Sapporo Medical University, Japan.
Sangyo Eiseigaku Zasshi. 1996 Jul;38(4):158-64.
The purpose of this study was to investigate the relation between nerve conduction velocity (NCV) and some factors which affect the measurement, such as age, skin temperature, body build and alcohol consumption. Neurophysiological parameters of healthy volunteers (28 males and 27 females, aged 20-57 years) who were free from occupational exposure inducing neuropathy were determined by monitoring skin temperature. A questionnaire survey on height, alcohol and tobacco consumption was also performed. The following results were obtained: 1) Analysis of covariance to examine the relation between age groups and NCVs adjusting for skin temperature showed significant differences only in peroneal motor distal latency (MDL) and duration of sural sensory nerve action potential (SNAP) between age groups. However, there was no constant relation between these parameters and age. Multiple regression analysis showed the significant relationships between age and ulnar MDL and the duration of sural sensory nerve action potential, adjusting for sex, height, weight, BMI, alcohol intake (frequency/week, ethanol equivalent ml/week), tobacco consumption (/day), skin temperature and education years. 2) The skin temperature had significant effects on ulnar MDL, ulnar sensory NCV, duration of ulnar SNAP, sural sensory NCV and amplitude and duration of sural SNAP according to the results of multiple regression analysis and analysis of variance. 3) The body mass index had an independent effect on the ulnar nerve conduction, shortening MDL and the duration of the sensory nerve action potential. 4) Consumption of alcohol and tobacco had no significant relation to nerve conduction velocity in our study. These results show that skin temperature is a major covariate of peripheral nerve conduction and that it is very important to control skin temperature in studies on nerve conduction measurements.
本研究的目的是调查神经传导速度（NCV）与一些影响测量的因素之间的关系，这些因素包括年龄、皮肤温度、体型和酒精摄入量。通过监测皮肤温度，确定了无职业性暴露导致神经病变的健康志愿者（28名男性和27名女性，年龄在20 - 57岁之间）的神经生理参数。还进行了关于身高、酒精和烟草消费的问卷调查。获得了以下结果：1）通过协方差分析来检验年龄组与经皮肤温度校正后的NCV之间的关系，结果显示仅在腓总运动神经远端潜伏期（MDL）和腓肠感觉神经动作电位（SNAP）持续时间方面，年龄组之间存在显著差异。然而，这些参数与年龄之间没有固定关系。多元回归分析显示，在调整性别、身高、体重、体重指数、酒精摄入量（每周频率、每周乙醇当量毫升数）、烟草消费量（每天）、皮肤温度和受教育年限后，年龄与尺神经MDL以及腓肠感觉神经动作电位持续时间之间存在显著关系。2）根据多元回归分析和方差分析结果，皮肤温度对尺神经MDL、尺神经感觉NCV、尺神经SNAP持续时间、腓肠感觉NCV以及腓肠SNAP的幅度和持续时间有显著影响。3）体重指数对尺神经传导有独立影响，可缩短MDL和感觉神经动作电位的持续时间。4）在我们的研究中，酒精和烟草消费与神经传导速度没有显著关系。这些结果表明，皮肤温度是周围神经传导的主要协变量，并且在神经传导测量研究中控制皮肤温度非常重要。
