Mahendra P, Richards E M, Sinclair P, Nacheva E, Marcus R E
Department of Haematology, Addenbrooke's NHS Trust, Cambridge, UK.
Clin Lab Haematol. 1996 Jun;18(2):121-2. doi: 10.1046/j.1365-2257.1996.00162.x.
A 42-year-old male patient with a history of occupational exposure to benzene presented with pancytopenia. His bone marrow showed evidence of trilineage dysplasia and cytogenetic analysis revealed a unique t(9;13)(q34;q12) translocation. Five months after diagnosis he developed secondary AML. He was treated with four courses of chemotherapy and an autologous bone marrow transplantation (BMT). Four years post-transplantation he remains in haematological and morphological remission though the cytogenetic abnormality is still present in all metaphases examined.
一名有苯职业暴露史的42岁男性患者出现全血细胞减少。其骨髓显示有三系发育异常的证据，细胞遗传学分析发现一种独特的t(9;13)(q34;q12)易位。诊断后5个月，他发展为继发性急性髓系白血病（AML）。他接受了四个疗程的化疗及一次自体骨髓移植（BMT）。移植后四年，尽管在所有检查的中期相中细胞遗传学异常仍然存在，但他仍处于血液学和形态学缓解状态。
