利福布汀的诱导特性及其对同时使用药物的药代动力学和代谢的影响。
Inducing properties of rifabutin, and effects on the pharmacokinetics and metabolism of concomitant drugs.
作者信息
Benedetti M S
机构信息
Pharmacia, Research and Development, Milan, Italy.
出版信息
Pharmacol Res. 1995 Oct;32(4):177-87. doi: 10.1016/s1043-6618(05)80021-0.
Rifabutin, a rifamycin derivative like rifampicin, has been registered for the treatment of pulmonary tuberculosis and for the prophylaxis and treatment of MAC in patients with AIDS. Rifabutin induces cytochrome P-450 3A4. The effect of rifabutin on the pharmacokinetics and metabolism of drugs administered concomitantly to humans (isoniazid, ethambutol, zidovudine, didanosine, delavirdine, fluconazole, itraconazole, methadone, clarithromycin, theophylline and cyclosporin) has been reviewed.
利福布汀是一种类似利福平的利福霉素衍生物，已被注册用于治疗肺结核以及预防和治疗艾滋病患者的鸟分枝杆菌复合体感染。利福布汀可诱导细胞色素P - 450 3A4。本文综述了利福布汀对同时给予人类的药物（异烟肼、乙胺丁醇、齐多夫定、去羟肌苷、地拉韦定、氟康唑、伊曲康唑、美沙酮、克拉霉素、茶碱和环孢素）的药代动力学和代谢的影响。
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