Jordan M K, Polis M A, Kelly G, Narang P K, Masur H, Piscitelli S C
Department of Pharmacy, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Antimicrob Agents Chemother. 2000 Aug;44(8):2170-2. doi: 10.1128/AAC.44.8.2170-2172.2000.
Ten human immunodeficiency virus-infected patients were given rifabutin in addition to fluconazole and clarithromycin. There was a 76% increase in the area under the concentration-time curve of rifabutin when either fluconazole or clarithromycin was given alone and a 152% increase when both drugs were given together with rifabutin. Patients should be monitored for adverse effects of rifabutin administered concomitantly with clarithromycin and/or fluconazole.
10名感染人类免疫缺陷病毒的患者在服用氟康唑和克拉霉素的基础上还加用了利福布汀。单独服用氟康唑或克拉霉素时，利福布汀的浓度-时间曲线下面积增加了76%，而当这两种药物与利福布汀一起服用时，该面积增加了152%。对于同时服用克拉霉素和/或氟康唑的患者，应监测利福布汀的不良反应。
