Ghosh K K, Goodchild A K, Sefton A E, Martin P R
Department of Physiology F13, University of Sydney, NSW, Australia.
J Comp Neurol. 1996 Feb 26;366(1):76-92. doi: 10.1002/(SICI)1096-9861(19960226)366:1<76::AID-CNE6>3.0.CO;2-H.
We studied the morphology of retinal ganglion cells in a diurnal New World primate, the marmoset Callithrix jacchus. This species is of interest as a model for primate vision because it has good behavioural visual acuity, and the retina and subcortical visual pathways are very similar to those of Old World monkeys and humans. Ganglion cells were labelled by placing small crystals of the carbocyanin dye DiI into the optic fibre layer, or by intracellular injection of neurobiotin. Two main classes of ganglion cell were labelled. We call these Group A cells and Group B cells: they are respectively homologous to parasol and midget cell classes. Group A and Group B cells show similar patterns of dye coupling, dendritic stratification and dendritic field size as their counterparts in Old World monkeys and humans. A third group of cells, which we call Group C, is morphologically heterogeneous. Examples corresponding to wide-field ganglion cell types described in Old World primates were encountered. One subgroup of C cells has a morphology very similar to that of the small bistratified (blue-on) cell described in macaque retina, suggesting that this functional pathway is common to all primates. As for other New World monkeys, the marmoset shows a sex-linked polymorphism of cone pigment expression, such that all males are dichromats and the majority of females are trichromats. No systematic differences in Group B cells were seen between male and female retinas, suggesting that trichromacy is not accompanied by specific changes in ganglion cell morphology.
我们研究了一种昼行性新大陆灵长类动物——狨猴（Callithrix jacchus）视网膜神经节细胞的形态。该物种作为灵长类视觉模型备受关注，因为它具有良好的行为视觉敏锐度，其视网膜和皮层下视觉通路与旧大陆猴和人类的非常相似。通过将羰花青染料DiI的小晶体置于视神经纤维层，或通过细胞内注射神经生物素对神经节细胞进行标记。标记出了两类主要的神经节细胞。我们将其称为A组细胞和B组细胞：它们分别与伞状细胞和侏儒细胞类同源。A组和B组细胞在染料偶联、树突分层和树突野大小方面表现出与旧大陆猴和人类对应细胞相似的模式。第三组细胞，我们称之为C组，在形态上具有异质性。遇到了与旧大陆灵长类动物中描述的宽视野神经节细胞类型相对应的例子。C组细胞的一个亚组的形态与猕猴视网膜中描述的小双分层（蓝视锥细胞开启型）细胞非常相似，这表明这种功能通路在所有灵长类动物中都很常见。至于其他新大陆猴，狨猴表现出视锥色素表达的性连锁多态性，即所有雄性都是二色视者，而大多数雌性是三色视者。在雄性和雌性视网膜的B组细胞中未发现系统性差异，这表明三色视觉并不伴随着神经节细胞形态的特定变化。
