Najim Al-Din A S, Kurdi A, Mubaidin A, El-Khateeb M, Khalil R W, Wriekat A L
Faculty of Medicine, Amman, Jordan.
J Neurol Sci. 1996 Feb;135(2):162-7. doi: 10.1016/0022-510x(95)00276-8.
In a 2-year hospital-based study in Jordan 131 Arab multiple sclerosis patients were identified including 84 Palestinians and 36 Jordanians. Based on MS/ALS case ratio, multiple sclerosis was found to be twice as common among Palestinians than Jordanians. Other than the less marked female preponderance among Jordanian patients, the disease had the same clinical and paraclinical characteristics in both groups. It was more likely for Palestinian and Jordanian patients to originate from the northern parts of their countries, to be Rh negative and to be HLA-DR2 positive than their controls. Palestinians (patients and controls) did not show significant differences from Jordanians (patients and controls) in relation to their eye color, ABO and Rh blood groups distribution nor the HLA-DR or HLA-DQ (apart from HLA-DQ3) epitopes frequency, thus not offering any significant difference in the genetic-racial markers studies to explain the difference in the observed disease susceptibility. Previous studies demonstrated that 2 racially different populations sharing the same environment can have different risk of developing multiple sclerosis, but this study has shown that this can also be true for 2 racially similar populations sharing the same environment.
在约旦进行的一项为期两年的医院研究中，共确定了131名阿拉伯多发性硬化症患者，其中包括84名巴勒斯坦人和36名约旦人。基于多发性硬化症/肌萎缩侧索硬化症病例比率，发现巴勒斯坦人中多发性硬化症的发病率是约旦人的两倍。除了约旦患者中女性优势不太明显外，两组疾病的临床和辅助检查特征相同。与各自的对照组相比，巴勒斯坦和约旦患者更有可能来自本国北部地区，Rh血型呈阴性，且HLA-DR2呈阳性。巴勒斯坦人（患者和对照组）与约旦人（患者和对照组）在眼睛颜色、ABO和Rh血型分布以及HLA-DR或HLA-DQ（除HLA-DQ3外）抗原表位频率方面没有显著差异，因此在遗传种族标记研究中没有提供任何显著差异来解释观察到的疾病易感性差异。先前的研究表明，两个种族不同但共享相同环境的人群患多发性硬化症的风险可能不同，但这项研究表明，两个种族相似且共享相同环境的人群也可能如此。
