Gasilin V S, Romanov A I, Bykov I I, Paliĭ V I
Kardiologiia. 1977 Apr;17(4):5-10.
Monitoring and electrocardiographic observations were conducted in 900 patients during the acute and subacute periods of myocardial infarction. It was found that without preventive therapy arrhythmias develop in 85% of the patients, and with preventive antiarrhythmic treatment--in 75.5%. A combination of two and more types of arrhythmias was encountered in 42% of the cases. In the presence of routine therapy for myocardial infarction individual antiarrhythmic drugs displayed different efficacy. In supraventricular forms of arrhythmias the most effective drugs are Chinidin and Chinidin-Durules, Inderal and Hiluritmal, in ventricular forms--Lidokaine, Chinidin, Novocainamide, Inderal, Hiluritmal. A combined employment of these drugs against the background of potassium and magnesium salts administration, Inosie-F, water-soluble camphor and Cocarboxylase promoted the restoration of a normal sinus rhythm in 85% of the cases. When the drug therapy produced no antiarrhythmic effect and ventricular fibrillation developed, electroimpulse therapy was employed. In persistent atrioventricular blocks only cardiostimulation was effective.
对900例心肌梗死急性期和亚急性期患者进行了监测和心电图观察。发现未经预防性治疗时，85%的患者会发生心律失常，而经预防性抗心律失常治疗后，这一比例为75.5%。42%的病例出现了两种或更多类型心律失常的组合。在心肌梗死常规治疗的情况下，个别抗心律失常药物显示出不同的疗效。在室上性心律失常中，最有效的药物是奎尼丁和长效奎尼丁、心得安和乙胺碘呋酮；在室性心律失常中，是利多卡因、奎尼丁、普鲁卡因酰胺、心得安、乙胺碘呋酮。在给予钾盐和镁盐、肌醇-1,6-二磷酸、水溶性樟脑和羧化酶的背景下联合使用这些药物，85%的病例恢复了正常窦性心律。当药物治疗无抗心律失常作用且发生心室颤动时，采用电脉冲治疗。在持续性房室传导阻滞中，仅心脏刺激有效。
