Chizh V D
Kardiologiia. 1977 Apr;17(4):93-7.
A comparative assessment is presented for the effect of Obsiden, Isoptine, Novocainamide, or Chinidin on the phase structure of the cardiac cycle and on the ballistocardiogramme in 125 patients with arrhythmias of varying forms and genesis. A combined employment of Obsidan or Novocainamide with cardiac glycosides was associated with a worsening of the phase structure of the cardiac cycle; with a similar therapy with Isoptine the poly- and ballistocardiographic data improved significantly. The administration of Isoptine without cardiac glycosides resulted in a distinct impairment of these parameters, although prior to the administration of the drug these patients had no circulatory insufficiency. The observed negative effect of Chinidin upon the indices of poly- and ballistocardiography was substantial following preceeding therapy with Isoptine, and less distinct--following Obsiden treatment.
对125例不同类型和病因的心律失常患者，比较了奥昔旦、异搏定、普鲁卡因酰胺或奎尼丁对心动周期相位结构和心冲击图的影响。奥昔旦或普鲁卡因酰胺与强心苷联合使用会使心动周期的相位结构恶化；而使用异搏定进行类似治疗时，多项心冲击图数据显著改善。在未使用强心苷的情况下给予异搏定，尽管这些患者在用药前没有循环功能不全，但这些参数仍出现明显受损。在用异搏定进行前期治疗后，奎尼丁对多项心冲击图指标的负面影响很大，而在奥昔旦治疗后则不太明显。
